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V Gieselmann Selected Research

Metachromatic Leukodystrophy (Sulfatide Lipidosis)

2/2010Metachromatic leukodystrophy--an update.
3/2009Lysosulfatide regulates the motility of a neural precursor cell line via calcium-mediated process collapse.
3/2007Partial cure of established disease in an animal model of metachromatic leukodystrophy after intracerebral adeno-associated virus-mediated gene transfer.
12/2006Embryonic stem cell-based reduction of central nervous system sulfatide storage in an animal model of metachromatic leukodystrophy.
8/2006Modest phenotypic improvements in ASA-deficient mice with only one UDP-galactose:ceramide-galactosyltransferase gene.
10/2004Lysosomal sulfatide storage in the brain of arylsulfatase A-deficient mice: cellular alterations and topographic distribution.
7/2004Specific downregulation and mistargeting of the lipid raft-associated protein MAL in a glycolipid storage disorder.
12/2003Metachromatic leukodystrophy: consequences of sulphatide accumulation.
1/2002Bone marrow stem cell-based gene transfer in a mouse model for metachromatic leukodystrophy: effects on visceral and nervous system disease manifestations.
8/2001Lysosomal sulfoglycolipid storage in the kidneys of mice deficient for arylsulfatase A (ASA) and of double-knockout mice deficient for ASA and galactosylceramide synthase.
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V Gieselmann Research Topics

Disease

17Metachromatic Leukodystrophy (Sulfatide Lipidosis)
02/2010 - 03/2000
6Lysosomal Storage Diseases (Lysosomal Storage Disease)
12/2009 - 03/2000
6Demyelinating Diseases (Demyelinating Disease)
03/2007 - 05/2000
3Lipidoses
08/2006 - 07/2001
1Neuroblastoma
03/2009
1Disease Progression
09/2006
1Late Onset Disorders
03/2005
1Gliosis
12/2003
1Ganglion Cysts (Ganglion)
05/2001

Drug/Important Bio-Agent (IBA)

15Cerebroside-Sulfatase (Arylsulfatase A)IBA
02/2010 - 03/2000
9Sulfoglycosphingolipids (Sulfatides)IBA
03/2009 - 05/2001
4EnzymesIBA
03/2007 - 06/2001
4LipidsIBA
08/2006 - 07/2000
3SphingolipidsIBA
02/2010 - 07/2004
1psychosine-3'-sulfate esterIBA
03/2009
1RNA Splicing FactorsIBA
03/2005
1Proteins (Proteins, Gene)FDA Link
07/2004
1ArylsulfatasesIBA
12/2003
1Galactosylceramides (Galactocerebrosides)IBA
08/2001
1sulfoglycolipidsIBA
08/2001

Therapy/Procedure

1Enzyme Replacement Therapy
12/2009
1Bone Marrow Transplantation (Transplantation, Bone Marrow)
06/2001
1Therapeutics
06/2001